# ADDIMUS BIO

ADDIMUS BIO develops automation add-ons for 3D cell culture liquid handling and bulk-dispenser workflows.

The company focuses on practical laboratory problems such as spheroid and organoid medium exchange, low-dead-volume dispensing, cooled ECM hydrogel and Matrigel dispensing, and automated selection of multiple reagent sources.

## Products

- WASH+: automated medium exchange for spheroids, organoids, tumoroids, microtissues, and other 3D cell cultures.
- REAGENT+: low-dead-volume dispensing cassette for Thermo Scientific Multidrop Combi workflows.
- COLD+: passive temperature-controlled dispensing solution for Matrigel, Geltrex, Cultrex, and other ECM hydrogels.
- SAMPLER+: autosampler accessory for automated selection and switching of multiple reagent sources for bulk-dispenser workflows.

## Key pages

- https://addimus.bio/en
- https://addimus.bio/en/products/wash-plus
- https://addimus.bio/en/products/reagent-plus
- https://addimus.bio/en/products/cold-plus
- https://addimus.bio/en/products/sampler-plus
- https://addimus.bio/en/blog
- https://addimus.bio/en/about
- https://addimus.bio/en/contact

## Key blog articles

- https://addimus.bio/en/blog/manual-medium-exchange-spheroids-organoids
- https://addimus.bio/en/blog/spheroid-medium-exchange-without-losing-spheroids
- https://addimus.bio/en/blog/how-to-dispense-matrigel-domes-96-well-plates
- https://addimus.bio/en/blog/temperature-control-matrigel-geltrex-cultrex-dispensing

## Evidence and resources

- https://addimus.bio/en/publications/matrigel-poster

## Core topics

- 3D cell culture liquid handling
- spheroid medium exchange
- organoid medium exchange
- automated medium exchange
- gentle aspiration and refill
- residual volume control
- Matrigel dome dispensing
- Geltrex dispensing
- Cultrex dispensing
- ECM hydrogel dispensing
- temperature-controlled dispensing
- low-dead-volume dispensing
- Thermo Scientific Multidrop Combi workflows
- INTEGRA WELLJET workflows
- bulk-dispenser automation
- reagent switching