Poster
Gentle automated media exchange for 3D spheroid cultures
Poster covering low-shear medium exchange in 96- and 384-well plates with zero tissue loss after repeated wash cycles.
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Explore automation add-ons for medium exchange, low-dead-volume dispensing, cooled hydrogel workflows, and multi-reagent bulk dispensing.
WASH+
Eliminate the bottleneck of manual media exchange. Our automated solution, powered by the INTEGRA WELLJET, delivers gentle, low-shear liquid handling for spheroids, organoids and Matrigel domes. Compatible with 96- and 384-well formats, such as U-bottom plates or InSphero Akura™ plates, our system achieves <5 µL residual volume with 0% tissue loss. Experience true walk-away automation with throughput exceeding 20 plates per hour.
Explore WASH+ for automated spheroid and organoid medium exchange
REAGENT+
Save precious reagents such as Matrigel, enzymes, antibodies or primary cells. REAGENT+ features a dead volume as low as 100 µL, which is a ten-fold reduction compared to conventional dispensing cassettes. It is compatible with standard MultiDrop Combi devices.
Explore REAGENT+ for low-dead-volume dispensing
COLD+
Unlock the full potential of your bulk dispenser with COLD+, the first passive cooling cassette designed specifically for 3D cell culture automation. By integrating advanced phase-change cooling and precision nozzle geometry, COLD+ enables the reliable, high-speed dispensing of e.g. 4 µL domes directly into the center of 96-well plates. Eliminate the variability of manual pipetting and the high cost of reagent waste. COLD+ keeps your matrix liquid, such as Matrigel, below 10°C, your cells viable, and your dead volume under 100 µL.
Explore COLD+ for cooled Matrigel and hydrogel dispensing
SAMPLER+
The SAMPLER+ Autosampler enables you to use 20+ reagents without any manual changeovers. From 15 mL tubes to 1 L bottles, a large variety of different containers can be installed. This solution is compatible with most bulk dispensers such as the ThermoFisher MultiDrop Combi, Integra WELLJET, Agilent Biotek Washer/Dispenser, etc. The SAMPLER+ allows you to perform highly automated screens, automatically sterilize and clean your cassette before or after each use, or to fill each row in a plate with a different reagent.
Explore SAMPLER+ for multi-reagent bulk dispensingResources and evidence
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Application note
Automated medium exchange in Akura 384-well plates
Workflow details for gentle media exchange with 5 µL residual volume in Akura plates for sensitive 3D cell culture models.
Open application notePoster
Cooled dispensing of microliter-scale Matrigel domes
Practical poster on cooled hydrogel dispensing workflows using off-the-shelf bulk dispensers and passive cooling hardware.
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